Thiabendazole CAS#148-79-8

CAS Number: 148-79-8
Chemical Formula: C10H7N3S
Synonyms:

STORITE
TBZ
THIABENDAZOL

Appearance: Yellow Powder

MOQ (Minimum Order Quantity): 1 FCL (Full Container Load)

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Thiabendazole CAS#148-79-8

Thiabendazole is a kind of fungicide and parasiticide. As a fungicide, it can be used for the treatment of mold, blight and many other fungal diseases occurring in fruits and vegetable. As an antiparasitic, it is capable of treating roundworms, hookworms, and other kinds of helminth species that can attack wild animals, livestock and humans. It also has effects of inhibiting the angiogenesis of cells. The mechanism of action is still not fully understood. It has found that Thiabendazole is capable of suppressing the helminth-specific mitochondrial enzyme fumarate reductase, further inhibiting the citric acid cycle, mitochondrial respiration and ATP production, leading to helminth’s death. It may also inhibit the microtubule polymerization processes.

Thiabendazole Chemical Properties

Melting point	298-301°C
Boiling point	446.0±37.0 °C(Predicted)
density	1.2271 (rough estimate)
vapor pressure	Negligible at room temperature
refractive index	1.5500 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Soluble in methanol and dimethyl sulfoxide.
pka	pKa 4.7 (Uncertain)
form	powder
color	light yellow
Water Solubility	0.005 g/100 mL
Merck	14,9289
BRN	611403
Cosmetics Ingredients Functions	ANTIMICROBIAL
InChI	1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
InChIKey	WJCNZQLZVWNLKY-UHFFFAOYSA-N
SMILES	c1ccc2[nH]c(nc2c1)-c3cscn3
LogP	2.470
CAS DataBase Reference	148-79-8(CAS DataBase Reference)
NIST Chemistry Reference	Thiabendazole(148-79-8)
EPA Substance Registry System	Thiabendazole (148-79-8)

Safety Information

Hazard Codes	N,Xi
Risk Statements	50/53-36/37/38
Safety Statements	60-61-36-26
RIDADR	UN 3077 9/PG 3
WGK Germany	2
RTECS	DE0700000
TSCA	TSCA listed
HazardClass	9
PackingGroup	III
HS Code	29341000
Storage Class	11 - Combustible Solids
Hazard Classifications	Aquatic Acute 1 Aquatic Chronic 1
Hazardous Substances Data	148-79-8(Hazardous Substances Data)
Toxicity	LD50 in mice, rats, rabbits (g/kg): 3.6, 3.1, >3.8 orally (Robinson)

Product Application Of Thiabendazole CAS#148-79-8

Thiabendazole; a thiazolyl benzimidazole available for oral administration. It is active against most common intestinal nematodes. As a result of its larvicidal and ovicidal activity, it is effective in strongyloidiasis, trichinosis, visceral larva migrans and cutaneous larva migrans.
It is well absorbed from the small intestine. Peak plasma levels are reached about 1–2 h after a single oral dose of the suspension. It is extensively metabolized in the liver to the 5-hydroxy derivative, which is inactive. Most of the drug is excreted within 24 h. About 90% is excreted in the urine, chiefly as glucuronide or sulfate conjugates; the remainder is passed in the feces.
A wide range of unpleasant side effects occur, including nausea and other gastrointestinal upsets, fever and neurological effects. It has been largely replaced by the less toxic benzimidazole carbamates. Although active against Ascaris lumbricoides, E. vermicularis and hookworms, it should not be used as primary therapy for these infections.

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